abstract：:Stressful events can have both short- and long-term effects on the brain. Our recent investigation identified short-term white matter integrity (WMI) changes in 30 subjects soon after the Japanese earthquake. Our findings suggested that lower WMI in the right anterior cingulum (Cg) was a pre-existing vulnerability fac...

journal_title：BioMed research international

authors： Sekiguchi A,Kotozaki Y,Sugiura M,Nouchi R,Takeuchi H,Hanawa S,Nakagawa S,Miyauchi CM,Araki T,Sakuma A,Taki Y,Kawashima R

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Data about endocrine and bone disease in nontransfusion-dependent thalassaemia (NTDT) is scanty. The aim of our study was to evaluate these complications in β-TI adult patients. METHODS:We studied retrospectively 70 β-TI patients with mean followup of 20 years. Data recorded included age, gender, haemoglobin...

journal_title：BioMed research international

authors： Baldini M,Marcon A,Cassin R,Ulivieri FM,Spinelli D,Cappellini MD,Graziadei G

更新日期：2014-01-01 00:00:00

abstract：:In orthopaedic surgery and sports medicine, the knee joint has traditionally been considered the workhorse. The reconstruction of every damaged element in this joint is crucial in achieving the surgeon's goal to restore the knee function and prevent degeneration towards osteoarthritis. In the last fifteen years, the f...

journal_title：BioMed research international

authors： Sánchez M,Delgado D,Sánchez P,Fiz N,Azofra J,Orive G,Anitua E,Padilla S

更新日期：2014-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder caused by selective loss of dopaminergic neurons in the substantia nigra pars compacta which leads to dysfunction of cerebral pathways critical for the control of movements. The diagnosis of PD is based on motor symptoms, such as bradykinesia, akinesia, muscular...

journal_title：BioMed research international

authors： Ciurleo R,Di Lorenzo G,Bramanti P,Marino S

更新日期：2014-01-01 00:00:00

abstract：:Interest is rising for animal modeling of pathological gambling. Using the operant probabilistic-delivery task (PDT), gambling proneness can be evaluated in laboratory animals. Drawing a comparison with rats, this study evaluated the common marmoset (Callithrix jacchus) using a PDT. By nose- or hand-poking, subjects l...

journal_title：BioMed research international

authors： Zoratto F,Sinclair E,Manciocco A,Vitale A,Laviola G,Adriani W

更新日期：2014-01-01 00:00:00

abstract：:Recent studies have shown that sumoylation is a posttranslational modification involved in regulation of the transforming growth factor-β (TGF-β) signaling pathway, which plays a critical role in renal fibrosis in diabetic nephropathy (DN). However, the role of sumoylation in the regulation of TGF-β signaling in DN is...

journal_title：BioMed research international

authors： Zhou X,Gao C,Huang W,Yang M,Chen G,Jiang L,Gou F,Feng H,Ai N,Xu Y

更新日期：2014-01-01 00:00:00

abstract：:The zebrafish constitutes a powerful model organism with unique advantages for investigating the vertebrate circadian timing system and its regulation by light. In particular, the remarkably early and rapid development of the zebrafish circadian system has facilitated exploring the factors that control the onset of ci...

journal_title：BioMed research international

authors： Ben-Moshe Z,Foulkes NS,Gothilf Y

更新日期：2014-01-01 00:00:00

abstract：:The use of supplemental oxygen in uncomplicated cesarean deliveries under spinal anesthesia has been thoroughly investigated during recent decades. The aim of this study was to determine the benefits for both mother and infant of administering supplemental, low-dose oxygen via a nasal cannula versus having no suppleme...

journal_title：BioMed research international

authors： Siriussawakul A,Triyasunant N,Nimmannit A,Ngerncham S,Hirunkanokpan P,Luang-Aram S,Pechpaisit N,Wangdee A,Ruangvutilert P

更新日期：2014-01-01 00:00:00

abstract：:Ablative therapies have been utilized with increasing frequency for the treatment of Barrett's esophagus with and without dysplasia. Multiple modalities are available for topical ablation of the esophagus, but radiofrequency ablation (RFA) remains the most commonly used. There have been significant advances in techniq...

journal_title：BioMed research international

authors： Tuttle R,Nurkin SJ,Hochwald SN

更新日期：2014-01-01 00:00:00

abstract：:Body weight supported locomotor training uses neuroplasticity principles to improve recovery following a spinal cord injury (SCI). Steady state locomotion using the same body weight support (BWS) percent was compared in 7 males (42.6 ± 4.29 years) with incomplete SCI and matched (gender, age) noninjured controls (42.7...

journal_title：BioMed research international

authors： Fenuta AM,Hicks AL

更新日期：2014-01-01 00:00:00

abstract：:Optical molecular imaging, a new medical imaging technique, is developed based on genomics, proteomics and modern optical imaging technique, characterized by non-invasiveness, non-radiativity, high cost-effectiveness, high resolution, high sensitivity and simple operation in comparison with conventional imaging modali...

journal_title：BioMed research international

authors： Chen ZY,Wang YX,Yang F,Lin Y,Zhou QL,Liao YY

更新日期：2014-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease and its targeting of the joints indicates the presence of a candidate autoantigen(s) in synovial joints. Patients with RA show immune responses in their peripheral blood to proteoglycan (PG) aggrecan. One of the most relevant animal models of RA appears to be ...

journal_title：BioMed research international

authors： Hanyecz A,Olasz K,Tarjanyi O,Nemeth P,Mikecz K,Glant TT,Boldizsar F

更新日期：2014-01-01 00:00:00

abstract：:Women's relative lack of decision-making power and their unequal access to employment, finances, education, basic health care, and other resources are considered to be the root causes of their ill-health and that of their children. The main purpose of this paper is to examine the interactive relation between women's e...

journal_title：BioMed research international

authors： Zaky HH,Armanious DM,Hussein MA

更新日期：2014-01-01 00:00:00

abstract：:We previously found that the greatest salivation response in healthy human subjects is produced by facial vibrotactile stimulation of 89 Hz frequency with 1.9 μ m amplitude (89 Hz-S), as reported by Hiraba et al. (2012, 20011, and 2008). We assessed relationships between the blood flow to brain via functional near-inf...

journal_title：BioMed research international

authors： Hiraba H,Inoue M,Gora K,Sato T,Nishimura S,Yamaoka M,Kumakura A,Ono S,Wakasa H,Nakayama E,Abe K,Ueda K

更新日期：2014-01-01 00:00:00

abstract：:Mitochondrial uncoupling protein 2 (UCP2) is suggested to have a role in the development of nonalcoholic steatohepatitis (NASH). However, the mechanism remains unclear. Autophagy is an important mediator of many pathological responses. This study aims to investigate the relationship between UCP2 and hepatoma cells aut...

journal_title：BioMed research international

authors： Lou J,Wang Y,Wang X,Jiang Y

更新日期：2014-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the second leading cause of cancer deaths in Taiwan. CD44, one of the well-known tumor markers, plays an essential role in tumor cell differentiation, invasion, and metastasis. We investigated the CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors related to H...

journal_title：BioMed research international

authors： Chou YE,Hsieh MJ,Chiou HL,Lee HL,Yang SF,Chen TY

更新日期：2014-01-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) is now one of the three leading causes of acute kidney injury in the world. A lot is known about the risk factors of CIN, yet it remains a major cause of morbidity, end stage renal disease, prolonged hospital stay, and increased costs as well as a high mortality. Many patients underg...

journal_title：BioMed research international

authors： Kalyesubula R,Bagasha P,Perazella MA

更新日期：2014-01-01 00:00:00

abstract：:Our research investigates the serum levels of three angiogenic factors in the AF family, namely, placenta growth factor (PlGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), in 54 patients with SLE (SLE group) and 28 healthy controls (normal control) through ELISA measurement. A...

journal_title：BioMed research international

authors： Zhou L,Lu G,Shen L,Wang L,Wang M

更新日期：2014-01-01 00:00:00

abstract：:A 35 KDa protein referred to as F3 was purified from the seeds of Borreria hispida by precipitation with 80% ammonium sulphate and gel filtration on Sephadex G-100 column. RP-HPLC analysis of protein fraction (F3) on an analytical C-18 column produced a single peak, detected at 220 nm. F3 showed an apparent molecular ...

journal_title：BioMed research international

authors： Rupachandra S,Sarada DV

更新日期：2014-01-01 00:00:00

abstract：PURPOSE:Recovery of walking outdoors after hip fracture is important for equal participation in the community. The causes of poor recovery are not fully understood. This study investigates recovery of walking outdoors and associated determinants after hip fracture. METHODS:A prospective follow-up study, among clinical...

journal_title：BioMed research international

authors： Salpakoski A,Törmäkangas T,Edgren J,Sihvonen S,Pekkonen M,Heinonen A,Pesola M,Kallinen M,Rantanen T,Sipilä S

更新日期：2014-01-01 00:00:00

abstract：:Human mesenchymal stem cells (MSCs) have an intrinsic property for homing towards tumor sites and can be used as tumor-tropic vectors for tumor therapy. But very limited studies investigated the antitumor properties of MSCs themselves. In this study we investigated the antiglioma properties of two easily accessible MS...

journal_title：BioMed research international

authors： Yang C,Lei D,Ouyang W,Ren J,Li H,Hu J,Huang S

更新日期：2014-01-01 00:00:00

abstract：INTRODUCTION:Deep vein thrombosis (DVT) is a severe complication after total hip arthroplasty (THA). It leads to acute pulmonary embolism, a life-threatening disease. P-selectin is a 140-kDa transmembrane glycoprotein. Elevated P-selectin was associated with 1.7-fold increase in the risk of venous thrombosis. MATERIAL...

journal_title：BioMed research international

authors： Shi D,Xu X,Xu Z,Nakamura T,Pang Y,Yao C,Wang F,Chen D,Dai J,Jiang Q

更新日期：2014-01-01 00:00:00

abstract：:Contrast-induced acute kidney injury (CI-AKI) is commonly defined as a decline in kidney function occurring in a narrow time window after administration of iodinated contrast material. The incidence of AKI after contrast material administration greatly depends on the specific definition and cutoff values used. Althoug...

journal_title：BioMed research international

authors： Meinel FG,De Cecco CN,Schoepf UJ,Katzberg R

更新日期：2014-01-01 00:00:00

abstract：:Resveratrol has recently been used as a supplemental treatment for several neurological and nonneurological diseases. It is not known whether resveratrol has neuroprotective effect on amyotrophic lateral sclerosis (ALS). To assess the effect of resveratrol on the disease, we tested this agent on an ALS model of SOD1(G...

journal_title：BioMed research international

authors： Song L,Chen L,Zhang X,Li J,Le W

更新日期：2014-01-01 00:00:00

abstract：:Excessive ethanol consumption is one of the main causes of liver fibrosis. However, direct effects of ethanol exposure on endothelial cells and their contribution to fibrogenesis and metastasis were not investigated. Therefore we analysed whether ethanol directly affects endothelial cells and if this plays a role duri...

journal_title：BioMed research international

authors： Raskopf E,Gonzalez Carmona MA,Van Cayzeele CJ,Strassburg C,Sauerbruch T,Schmitz V

更新日期：2014-01-01 00:00:00

abstract：:Dengue fever, a reemerging disease, is putting nearly 2.5 billion people at risk worldwide. The number of infections and the geographic extension of dengue fever infection have increased in the past decade. The disease is caused by the dengue virus, a flavivirus that uses mosquitos Aedes sp. as vectors. The disease ha...

journal_title：BioMed research international

authors： De La Guardia C,Lleonart R

更新日期：2014-01-01 00:00:00

abstract：:Autoimmunity remains a complex physiologic deviation, enabled and perpetuated by a variety of interplayers and pathways. Simplistic approaches, targeting either isolated end-effectors of more centrally placed interactors of these mechanisms, are continuously tried in an effort to comprehend and halt cascades with pote...

journal_title：BioMed research international

authors： Pateinakis P,Pyrpasopoulou A

更新日期：2014-01-01 00:00:00

abstract：:Data on genotypic diversity of Mycobacterium tuberculosis complex (MTBC) is important to understand its epidemiology, human adaptation, clinical phenotypes, and drug resistance. This study aimed to characterize MTBC clinical isolates circulating in a predominantly pastoralist area in Ethiopia, a country where tubercul...

journal_title：BioMed research international

authors： Belay M,Ameni G,Bjune G,Couvin D,Rastogi N,Abebe F

更新日期：2014-01-01 00:00:00

abstract：:The study of the normal function and pathology of the inner ear has unique difficulties as it is inaccessible during life and, so, conventional techniques of pathologic studies such as biopsy and surgical excision are not feasible, without further impairing function. Mathematical modelling is therefore particularly at...

journal_title：BioMed research international

authors： Bellos C,Rigas G,Spiridon IF,Bibas A,Iliopoulou D,Böhnke F,Koutsouris D,Fotiadis DI

更新日期：2014-01-01 00:00:00

abstract：:To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and ...

journal_title：BioMed research international

authors： Guo L,Yang S,Zhao Y,Zhang H,Wu Q,Chen F

更新日期：2014-01-01 00:00:00

abstract：:A cross-sectional study was carried out to determine the arsenic (As) and cadmium (Cd) concentrations in blood, urine, and drinking water as well as the health implications on 100 residents in an urban and a rural community. Results showed the blood As, urinary Cd, DNA damage, and water As and Cs were significantly (P...

journal_title：BioMed research international

authors： Zailina H,Najibah H,Aiezzati AN,Praveena SM,Patimah I

更新日期：2014-01-01 00:00:00

abstract：:Tumors and wounds share many similarities including loss of tissue architecture, cell polarity and cell differentiation, aberrant extracellular matrix (ECM) remodeling (Ballard et al., 2006) increased inflammation, angiogenesis, and elevated cell migration and proliferation. Whereas these changes are transient in repa...

journal_title：BioMed research international

authors： Tolg C,McCarthy JB,Yazdani A,Turley EA

更新日期：2014-01-01 00:00:00

abstract：:Toll-like receptors (TLRs), a critical family of pattern recognition receptors (PRRs), are responsible for the innate immune responses via signalling pathways to provide effective host defence against pathogen infections. However, TLR-signalling pathways are also likely to stringently regulate tissue maintenance and h...

journal_title：BioMed research international

authors： He X,Jing Z,Cheng G

更新日期：2014-01-01 00:00:00

abstract：:Gold nanoparticles (AuNPs) have several potential biological applications as well as excellent biocompatibility. AuNPs with surface modification using polyethylene glycol (PEG-AuNPs) can facilitate easy conjugation with various biological molecules of interest. To examine the anticancer bioactivity of PEG-AuNPs, we in...

journal_title：BioMed research international

authors： Huang YC,Yang YC,Yang KC,Shieh HR,Wang TY,Hwu Y,Chen YJ

更新日期：2014-01-01 00:00:00

abstract：:Spasticity is the velocity-dependent increase in muscle tone due to the exaggeration of stretch reflex. It is only one of the several components of the upper motor neuron syndrome (UMNS). The central lesion causing the UMNS disrupts the balance of supraspinal inhibitory and excitatory inputs directed to the spinal cor...

journal_title：BioMed research international

authors： Trompetto C,Marinelli L,Mori L,Pelosin E,Currà A,Molfetta L,Abbruzzese G

更新日期：2014-01-01 00:00:00

abstract：:Spinal cord injured (SCI) individuals show an altered hemodynamic response to metaboreflex activation due to a reduced capacity to vasoconstrict the venous and arterial vessels below the level of the lesion. Exercise training was found to enhance circulating catecholamines and to improve cardiac preload and venous ton...

journal_title：BioMed research international

authors： Milia R,Roberto S,Marongiu E,Olla S,Sanna I,Angius L,Bassareo P,Pinna M,Tocco F,Concu A,Crisafulli A

更新日期：2014-01-01 00:00:00

abstract：:The objective of this study was to perform a structural characterization and evaluate the in vitro safety profile and in vitro antioxidant activity of liquid crystalline systems (LCS) with and without retinyl palmitate (RP). LCS containing polyether functional siloxane (PFS) as a surfactant, silicon glycol copolymer (...

journal_title：BioMed research international

authors： Oliveira MB,do Prado AH,Bernegossi J,Sato CS,Lourenço Brunetti I,Scarpa MV,Leonardi GR,Friberg SE,Chorilli M

更新日期：2014-01-01 00:00:00

abstract：:Both strict blood pressure (BP) control and improvements in BP profile such as BP variability are important for suppression of renal deterioration and cardiovascular complication in hypertension and chronic kidney disease (CKD). In the present study, we examined the beneficial effects of the single pill-based combinat...

journal_title：BioMed research international

authors： Azushima K,Uneda K,Tamura K,Wakui H,Ohsawa M,Kobayashi R,Dejima T,Kanaoka T,Maeda A,Toya Y,Umemura S

更新日期：2014-01-01 00:00:00

abstract：:Methylmercury, organic form of mercury, can increase the number of abnormal sperm and decrease sperm concentration and testosterone levels possibly due to the damage caused by reactive species to germ and Leydig cells. Maná-cubiu (Solanum sessiliflorum Dunal) is a native fruit from Amazon rich in iron, zinc, niacin, p...

journal_title：BioMed research international

authors： Frenedoso da Silva R,Missassi G,dos Santos Borges C,Silva de Paula E,Hornos Carneiro MF,Grotto D,Barbosa Junior F,De Grava Kempinas W

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVES:Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. MATERIAL AND METHODS:In a population-based survey in Turkey demographics, height, weight, blood pre...

journal_title：BioMed research international

authors： Hür E,Özişik M,Ural C,Yildiz G,Mağden K,Köse SB,Köktürk F,Büyükuysal Ç,Yildirim I,Süleymanlar G,Ateş K,Duman S

更新日期：2014-01-01 00:00:00